Today is World Sickle Cell Day, so we decided to spotlight this terrible condition. The signs of sickle cell according to the National Institute of Health are shortness of breath, headaches, coldness in the extremities and pale skin tone, visible on the thin membranes of skin inside eyelids, mouth and gums. In extreme cases the patient experiences sudden intense pain (called sickle cell crisis). Sickle cell affects 90,000 to 100,000 Americans and is a condition where blood cells become hard and distorted making them clog the veins and arteries in the body. This can result in splenic crisis (enlargement of the spleen), infections, pulmonary hypertension (increased blood pressure in the lungs) and stroke.